Effectiveness of mood stabilizers in prophylactic treatment of bipolar disorder

Introduction Prophylactic treatment during bipolar disorder aims to prevent recurrences and improve the functional level. Objectives Our aim was compare clinical effectiveness of lithium versus sodium valproate in prophylactic type 1 Methods Retrospective, longitudinal, comparative study conducted among 162 patients followed for hospitalized at Psychiatry A department Razi Hospital. The Alda scale time recurrence were used mood stabilizers. Results difference between two groups noted some variables. Lithium prescription associated with educational level, number depressive episodes, suicide attempts, previous other thymoregulators, polarity index episode use atypical antipsychotics. Valproate unipolar mania, manic predominant polarity, episode, presence psychotic features, long acting antipsychotics higher doses response by showed no significant mean score nor rate responders. We a on considering whole duration study. after one year Lithium, years comparable both groups. Survival curves earlier Lithium. Conclusions efficacy stabilizers comparable. occured under Disclosure Interest None Declared